Predictors of Right Ventricular Systolic Dysfunction in Non-Ischemic Dilated Cardiomyopathy: An Echocardiographic Study
Article Notes and Dates
International Cardiovascular Research Journal: March 31, 2016,
; e10307.Published Online: March 01, 2016
Article Type: Research Article; Received: January 17, 2015; Revised: June 22, 2015; Accepted: August 19, 2015
To Cite :
O , Avcı
A , Babur Güler
G , Omaygenc
O , Cakal
B , et al. Predictors of Right Ventricular Systolic Dysfunction in Non-Ischemic Dilated Cardiomyopathy: An Echocardiographic Study,
Int Cardio Res J.
Copyright © 2016, Shiraz University of Medical Sciences. .
Background: Right Ventricular (RV) functions are known to have an impact on determining the prognosis of patients with Non-Ischemic Dilated Cardiomyopathy (NICMP).
Objectives: This study aimed to investigate the echocardiographic determinants of RV systolic dysfunction in patients with NICMP.
Patients and Methods: This cross-sectional study was conducted on 79 patients with angiographically normal coronary arteries (mean age: 50.5 ± 12, mean Ejection Fraction (EF): 31 ± 4%) selected through purposive sampling The patients were divided into two groups based on their RV systolic function determined by tissue Doppler systolic velocities (RV-Sm): group A (RV-Sm ≥ 10 cm/s, N = 48) and group B (RV-Sm < 10 cm/s, N = 31). The two groups were compared regarding clinical, demographic, and echocardiographic variables using independent t-test and chi-square test.
Results: The patients with RV systolic dysfunction were found to have higher Brain Natriuretic Peptide (BNP) values (P = 0.006) and worse functional status (New York Heart Association (NYHA) III-IV, P = 0.04) compared to group A. Besides, univariate analysis of the echocardiographic parameters revealed that the patients in group B had significantly (all P values < 0.05) higher Left Atrial Volume Index (LAVI), higher degree of left ventricular diastolic dysfunction (represented by LV-E/Em), higher degree of Functional Mitral Regurgitation (FMR), higher estimated Pulmonary Artery Systolic Pressure (PASP), and higher degree of RV diastolic dysfunction (represented by RV-E/Em) Moreover, multivariate logistic regression analysis showed that severe FMR (P = 0.006) and RV-E/Em (P = 0.016) predicted RV systolic dysfunction independently.
Conclusions: Advanced FMR and worse RV diastolic functions emerged as the independent predictors of RV systolic dysfunction in NICMP correlating to functional status and BNP levels.