A Comparative Study on the Effect of Amiodarone and Metaprolol for Prevention of Arrythmias after Open Heart Surgery

AUTHORS

Nayeem‑ ul‑hassan 1 , * , Abdul Majeed Dar 1 , Mohd Lateef Wani 1 , Hilal Ahmad Rather 2 , Farooq Ahmad Ganie 1

1 Department of Cardiovascular and Thoracic Surgery, Sher-i- Kashmir Institute of Medical Sciences, Soura Srinagar, Kashmir, India

2 Department of Cardiology, Sher-i- Kashmir Institute of Medical Sciences, Soura Srinagar, Kashmir, India

How to Cite: ul‑hassan N, Majeed Dar A , Wani M L , Rather H A , Ganie F A . A Comparative Study on the Effect of Amiodarone and Metaprolol for Prevention of Arrythmias after Open Heart Surgery, Int Cardio Res J. 2017 ; 7(1):e12711.

ARTICLE INFORMATION

International Cardiovascular Research Journal: 7 (1); e12711
Published Online: June 30, 2017
Article Type: Research Article
Received: May 07, 2017
Accepted: February 18, 2013

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Abstract

Objectives: The aim of this study was to compare the effect of amiodarone and metaprolol in prevention of atrial fibrillation in patients, following open heart surgery.

Methods: This prospective study was carried out between May 2008 to Nov. 2010, and comprised a total of 50 patients with normal preoperative sinus rhythm undergoing open heart surgery using cardio pulmonary bypass.

Results: Mean age of patients was 47+2.7 years, of which 60% who developed atrial fibrillation aged from 51 to 60 years. Most patients (62%) were in NYHA Class III. Patients who received amiodarone showed significant improvement in LVEF compared to those treated with Metaprolol. Amiodarone treated group exhibited lesser incidence and short-lasting atrial fibrillation, lower ventricular rate, shorter hospitalization, and lesser cost of care than those in metaprolol group.

Conclusions: The present study showed that amiodarone was more efficient in controlling post-operative atrial fibrillation as compared to metaprolol. However, a larger randomized controlled trial is needed to corroborate the result of this study.

Keywords

Amiodarone Metaprolol Atrial Fibrillation

© 0, Shiraz University of Medical Sciences.

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