Early Diagnosis of Acute Coronary Syndrome with Sensitive Troponin I and Ischemia Modified Albumin

AUTHORS

MA Takhshid 1 , Javad Kojuri 2 , SMB Tabei 3 , * , AR Tavasouli 4 , S Heidary 4 , M Tabandeh 2

1 1Laboratory Sciences and Technology Research Center, Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran, Iran

2 Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Genetic Department, Shiraz University of Medical Sciences, Shiraz, Iran

4 Laboratory Sciences and Technology Research Center, Paramedical School,Shiraz University of Medical Sciences, Shiraz, Iran

How to Cite: Takhshid M , Kojuri J , Tabei S , Tavasouli A , Heidary S , et al. Early Diagnosis of Acute Coronary Syndrome with Sensitive Troponin I and Ischemia Modified Albumin, Int Cardio Res J. 2010 ; 4(4):e58472.

ARTICLE INFORMATION

International Cardiovascular Research Journal: 4 (4); e58472
Published Online: December 01, 2010
Article Type: Research Article
Received: September 20, 2017
Accepted: December 01, 2010
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Abstract

Background: In this study we compared the diagnostic performance of serum ischemia modified albumin (IMA) and sensitive cardiac troponin I (cTnI) assay for the detection of acute coronary syndrome (ACS) in patients presenting to the emergency department (ED) with acute chest pain.
Methods: A prospective study was conducted on 123 patients presenting to the ED within three hours of acute chest pain. A 12-lead ECG was recorded and IMA and cTnI were measured on arrival at the ED. After diagnostic testing, the patients were classified as either ACS (n=70) or non- ACS (n= 53). The results of IMA, ECG, and cTnI, alone and in combination, were correlated with final diagnoses.
Results: IMA showed higher sensitivity (84%) and negative predictive value (NPV, 88%) compared to cTnI (sensitivity 42%, NPV 66%) and ECG (sensitivity 58%, NPV 74%). Combined use of IMA, cTnI and ECG significantly improved the sensitivity (96%, P<0.05) and NPV (96%) of IMA. The diagnostic performance of IMA was similar in the case of non-ST-segment-elevation ACS (sensitivity 80%, NPV 80%). The sensitivity and specificity of IMA for diagnosis of acute myocardial infarction (AMI) were 88% and 48%, respectively.
Conclusion: Measuring IMA at the time of ED admission improves the early diagnosis of ACS and non-ST-segment-elevation ACS in patients with acute chest pain. However, the test is not an effective tool for diagnosis of AMI in patients with chest pain presenting to ED.

Keywords

Ischemia modified albumin cardiac troponin acute coronary syndrome

© 0, Shiraz University of Medical Sciences.

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