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Investigating the Efficiency of D-Dimer Test in the Diagnosis of Aortic Dissection: a systematic and meta-analysis study

AUTHORS

Iraj Ahmadi 1 , Samira Mis Qavam 2 , Kourosh Sayehmiri 3 , Mohamad Golitaleb 4 , Hamed Tavan ORCID 5 , *

1 Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran

2 Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, IR Iran

3 School of Medicine, Psychosocial Injuries Research Center, Ilam University of Medical sciences, Ilam, IR Iran

4 Department of Nursing, Arak University of Medical Sciences, Arak, Ilam, IR Iran

5 Student Research Committee, Ilam University of Medical Sciences, Ilam, IR Iran

How to Cite: Ahmadi I, Qavam S M, Sayehmiri K, Golitaleb M, Tavan H. Investigating the Efficiency of D-Dimer Test in the Diagnosis of Aortic Dissection: a systematic and meta-analysis study, Int Cardio Res J. 2018 ; 12(4):e67273.

ARTICLE INFORMATION

International Cardiovascular Research Journal: 12 (4); e67273
Published Online: December 15, 2018
Article Type: Research Article
Received: December 03, 2018
Accepted: October 27, 2018

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Abstract

Abstract:

Background: Aortic dissection is a rare and important emergency condition, which usually involves a high mortality rate. Yet, early diagnosis of the disorder would increase the survival rate significantly.

Objectives: The present systematic study and meta-analysis aimed at investigating the efficiency of D-dimer test in diagnosis of aortic dissection.

Materials and Methods: The data used in this study were extracted from PubMed, Scopus, Elsevier, Springer, and Willey databases. Specificity, D-dimer, Sensitivity, and Aortic Dissection were the valid keywords used to extract the related articles. Totally, 11 papers published during 1998 - 2007 were selected. I2 index was used to assess heterogeneity across the studies.

Results: A total of 596 subjects (averagely 54.5 ones in each study) were examined in the present research and 11 articles were entered into the final meta-analysis. According to the findings, the mean of the specificity test was 0.66 (0.54 - 0.78), with I2 index = 74.9% and p-value = 0.001. Additionally, the mean of the sensitivity test was 0.98 with I2 index = 606% and p-value = 0.381. Moreover, the mean D-dimer plasma level was 18.6 ug/mL in patients suffering from aortic dissection.

Conclusion: This study showed the high efficiency of D-dimer test in diagnosis of aortic dissection. Thus, physicians are recommended to apply this quick and inexpensive method when a final diagnosis has not been made yet. Early diagnosis of aortic dissection via D-dimer test would result in implementation of the necessary treatments, eventually leading to a significant decrease in mortality rate.

Keywords

Meta-Analysis Dimer Aorta

© 0, Shiraz University of Medical Sciences.

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