International Cardiovascular Research Journal

Published by: Kowsar

The Effect of Caffeic Acid Phenethyl Ester on Development of Left Ventricular Dysfunction in Cirrhotic Rats

Mahin Dianat 1 , Samira Saadatfard 2 , Mohammad Badavi 1 , Akram Ahangar Pour 1 and Najmeh Sadeghi 2 , *
Authors Information
1 Physiological Research Center, Department of Physiology, Faculty of Medicine Ahvaz Jundishapour University of Medical Sciences, Ahvaz, IR Iran
2 Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, IR Iran
Article information
  • International Cardiovascular Research Journal: 10 (4); e9806
  • Published Online: October 1, 2016
  • Article Type: Research Article
  • Received: December 18, 2015
  • Accepted: July 17, 2016

To Cite: Dianat M, Saadatfard S, Badavi M, Ahangar Pour A, Sadeghi N. et al. The Effect of Caffeic Acid Phenethyl Ester on Development of Left Ventricular Dysfunction in Cirrhotic Rats, Int Cardio Res J. Online ahead of Print ; 10(4):e9806.

Abstract
Copyright © 2016, Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Lee RF, Glenn TK, Lee SS. Cardiac dysfunction in cirrhosis. Best Pract Res Clin Gastroenterol. 2007; 21(1): 125-40[DOI][PubMed]
  • 2. Moller S, Henriksen JH. Cardiovascular dysfunction in cirrhosis. Pathophysiological evidence of a cirrhotic cardiomyopathy. Scand J Gastroenterol. 2001; 36(8): 785-94[PubMed]
  • 3. Liu H, Ma Z, Lee SS. Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. Gastroenterology. 2000; 118(5): 937-44[PubMed]
  • 4. Moller S, Henriksen JH. Cirrhotic cardiomyopathy: a pathophysiological review of circulatory dysfunction in liver disease. Heart. 2002; 87(1): 9-15[PubMed]
  • 5. Moller S, Henriksen JH. Cirrhotic cardiomyopathy. J Hepatol. 2010; 53(1): 179-90[DOI][PubMed]
  • 6. Oktar S, Aydin M, Yonden Z, Alcin E, Ilhan S, Nacar A. Effects of caffeic acid phenethyl ester on isoproterenol-induced myocardial infarction in rats. Anadolu Kardiyol Derg. 2010; 10(4): 298-302[DOI][PubMed]
  • 7. Okutan H, Ozcelik N, Yilmaz HR, Uz E. Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart. Clin Biochem. 2005; 38(2): 191-6[DOI][PubMed]
  • 8. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, et al. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res. 1999; 59(10): 2347-52[PubMed]
  • 9. Orban Z, Mitsiades N, Burke TJ, Tsokos M, Chrousos GP. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation. 2000; 7(2): 99-105[PubMed]
  • 10. Chen YJ, Shiao MS, Wang SY. The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anticancer Drugs. 2001; 12(2): 143-9[PubMed]
  • 11. Orsolic N, Terzic S, Mihaljevic Z, Sver L, Basic I. Effects of local administration of propolis and its polyphenolic compounds on tumor formation and growth. Biol Pharm Bull. 2005; 28(10): 1928-33[PubMed]
  • 12. Fesen MR, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, Kohn KW. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol. 1994; 48(3): 595-608[PubMed]
  • 13. Albukhari AA, Gashlan HM, El-Beshbishy HA, Nagy AA, Abdel-Naim AB. Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats. Food Chem Toxicol. 2009; 47(7): 1689-95[DOI][PubMed]
  • 14. Park EH, Kahng JH. Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res. 1999; 22(6): 554-8[PubMed]
  • 15. Wu WM, Lu L, Long Y, Wang T, Liu L, Chen Q, et al. Free radical scavenging and antioxidative activities of caffeic acid phenethyl ester (CAPE) and its related compounds in solution and membranes: a structure–activity insight. Food Chem. 2007; 105(1): 107-15
  • 16. Fadillioglu E, Oztas E, Erdogan H, Yagmurca M, Sogut S, Ucar M, et al. Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats. J Appl Toxicol. 2004; 24(1): 47-52[DOI][PubMed]
  • 17. Mollaoglu H, Gokcimen A, Ozguner F, Oktem F, Koyu A, Kocak A, et al. Caffeic acid phenethyl ester prevents cadmium-induced cardiac impairment in rat. Toxicology. 2006; 227(1-2): 15-20[DOI][PubMed]
  • 18. Ilhan A, Koltuksuz U, Ozen S, Uz E, Ciralik H, Akyol O. The effects of caffeic acid phenethyl ester (CAPE) on spinal cord ischemia/reperfusion injury in rabbits. Eur J Cardiothorac Surg. 1999; 16(4): 458-63[PubMed]
  • 19. Huang SS, Liu SM, Lin SM, Liao PH, Lin RH, Chen YC, et al. Antiarrhythmic effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia/reperfusion injury in rats. Clin Biochem. 2005; 38(10): 943-7[DOI][PubMed]
  • 20. Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG. Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2008; 248(1): 18-24[DOI][PubMed]
  • 21. Ogeturk M, Kus I, Colakoglu N, Zararsiz I, Ilhan N, Sarsilmaz M. Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. J Ethnopharmacol. 2005; 97(2): 273-80[DOI][PubMed]
  • 22. Mitchell GF, Jeron A, Koren G. Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol. 1998; 274(3 Pt 2)-51[PubMed]
  • 23. Liu Y, Binz J, Numerick MJ, Dennis S, Luo G, Desai B, et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest. 2003; 112(11): 1678-87[DOI][PubMed]
  • 24. Rivera-Huizar S, Rincon-Sanchez AR, Covarrubias-Pinedo A, Islas-Carbajal MC, Gabriel-Ortiz G, Pedraza-Chaverri J, et al. Renal dysfunction as a consequence of acute liver damage by bile duct ligation in cirrhotic rats. Exp Toxicol Pathol. 2006; 58(2-3): 185-95[DOI][PubMed]
  • 25. Koyu A, Ozguner F, Yilmaz H, Uz E, Cesur G, Ozcelik N. The protective effect of caffeic acid phenethyl ester (CAPE) on oxidative stress in rat liver exposed to the 900 MHz electromagnetic field. Toxicol Ind Health. 2009; 25(6): 429-34[DOI][PubMed]
  • 26. Payabvash S, Kiumehr S, Nezami BG, Zandieh A, Anvari P, Tavangar SM, et al. Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress. Liver Int. 2007; 27(4): 538-47[DOI][PubMed]
  • 27. Ebrahimkhani MR, Moezi L, Kiani S, Merat S, Dehpour AR. Opioid receptor blockade improves mesenteric responsiveness in biliary cirrhosis. Dig Dis Sci. 2008; 53(11): 3007-11[DOI][PubMed]
  • 28. De Angelis KLD, Oliveira AR, Dall'Ago P, Peixoto LRA, Gadonski G, Lacchini S, et al. Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats. Brazilian J Med Biol Res. 2000; 33(6): 635-41
  • 29. Liu H, Song D, Lee SS. Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat. Am J Physiol Gastrointest Liver Physiol. 2001; 280(1)-74[PubMed]
  • 30. Fernández-Martínez E, Pérez-Álvarez V, Tsutsumi V, Shibayama M, Muriel P. Chronic bile duct obstruction induces changes in plasma and hepatic levels of cytokines and nitric oxide in the rat. Experiment Toxicol Pathol. 2006; 58(1): 49-58
  • 31. Rabani V, Baharvand H, Pournasr B, Farzaneh Z. Animal models of liver cirrhosis and fibrosis. J Iran Anatomical Sci. 7: 163-84
  • 32. Braunwald EFA, Kasper DLL DL. Liver and biliary tract disorders. 2008; : 12-4
  • 33. Coban S, Yildiz F, Terzi A, Al B, Ozgor D, Ara C, et al. The effect of caffeic acid phenethyl ester (CAPE) against cholestatic liver injury in rats. J Surg Res. 2010; 159(2): 674-9[DOI][PubMed]
  • 34. Kus I, Colakoglu N, Pekmez H, Seckin D, Ogeturk M, Sarsilmaz M. Protective effects of caffeic acid phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats. Acta Histochem. 2004; 106(4): 289-97[DOI][PubMed]
  • 35. Russo A, Longo R, Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia. 2002; 73 Suppl 1-9[PubMed]
  • 36. Lu Y, Cederbaum AI. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med. 2008; 44(5): 723-38[DOI][PubMed]
  • 37. Mery PF, Pavoine C, Belhassen L, Pecker F, Fischmeister R. Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation. J Biol Chem. 1993; 268(35): 26286-95
  • 38. Ward CA, Liu H, Lee SS. Altered cellular calcium regulatory systems in a rat model of cirrhotic cardiomyopathy. Gastroenterology. 2001; 121(5): 1209-18[PubMed]
  • 39. Zhou Y, Fang SH, Ye YL, Chu LS, Zhang WP, Wang ML, et al. Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats. Acta Pharmacol Sin. 2006; 27(9): 1103-10[DOI][PubMed]
  • 40. Chang GJ, Chang CJ, Chen WJ, Yeh YH, Lee HY. Electrophysiological and mechanical effects of caffeic acid phenethyl ester, a novel cardioprotective agent with antiarrhythmic activity, in guinea-pig heart. Eur J Pharmacol. 2013; 702(1-3): 194-207[DOI][PubMed]
  • 41. Natarajan K, Singh S, Burke TR, Grunberger D, Aggarwal BB. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proceedings Nation Academy Sci. 1996; 93(17): 9090-5
  • 42. Zambruni A, Trevisani F, Caraceni P, Bernardi M. Cardiac electrophysiological abnormalities in patients with cirrhosis. J Hepatol. 2006; 44(5): 994-1002[DOI][PubMed]
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