The Effect of Rectal Acetaminophen on the Closure of Ductus Arteriosus in Premature Neonates: A Case Series Study

AUTHORS

Mazyar Vakiliamini ORCID 1 , Hooman Daryoushi 1 , Atefe Rangchi 1 , Abbas Aghaei ORCID 2 , 3 , *

1 Department of Pediatrics, Clinical Research Development Center, Imam Khomaini and Mohammad Kermanshahi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, IR Iran

2 Department of Epidemiology, Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, IR Iran

3 Department of Epidemiology, Clinical Research Development Center, Imam Khomaini and Mohammad Kermanshahi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, IR Iran

How to Cite: Vakiliamini M, Daryoushi H, Rangchi A, Aghaei A. The Effect of Rectal Acetaminophen on the Closure of Ductus Arteriosus in Premature Neonates: A Case Series Study, Int Cardio Res J. 2019 ; 13(1):e85178.

ARTICLE INFORMATION

International Cardiovascular Research Journal: 13 (1); e85178
Published Online: March 01, 2019
Article Type: Research Article
Received: October 09, 2018
Accepted: January 06, 2019

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Abstract

Background:

Patent Ductus Arteriosus (PDA) with 30% prevalence is regarded as a common and threatening condition in premature neonates.

Objectives:

The present study aimed to assess the effect of rectal acetaminophen on PDA treatment in premature neonates.

Methods:

This case series study was conducted on all premature neonates with PDA admitted in Neonatal Intensive Care Unit (NICU) in Dr. Mohammad Kermanshahi Hospital affiliated to Kermanshah University of Medical Sciences (KUMS) during one year (2017). The subjects had contraindications for simultaneous administration of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and oral medications. Finally, 18 neonates (nine males and nine females) were studied. The patients were treated with 25 mg/kg rectal acetaminophen as the loading dose followed by 15 mg/kg/8 h for three days. Diagnosis and correction of PDA before and after the treatment were justified by echocardiography. Finally, statistical analyses were performed using chi-square and Mann-Whitney tests.

Results:

About 95% of the neonates responded to the treatment, while the response rate for oral ibuprofen and oral acetaminophen was 70 - 75% based on the results of the previous studies. The results indicated no statistically significant relationships among gestational age, birth weight, and the time of using rectal acetaminophen in two treatment steps of the study (P values = 0.898, 0.281, and 0.219, respectively).

Conclusion:

Rectal acetaminophen is suggested as an influential, safe, and cost-effective therapeutic option for PDA closure in preterm neonates with gestational age < 35 weeks.

 

 

Keywords

Acetaminophen Ductus Arteriosus Rectal

© 0, Shiraz University of Medical Sciences.

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